National Geographic : 2004 Jun
ZOCOR®(simvastatin) unless itis highly unlikely they will become pregnant Ifa woman does become pregnant while taking ZOCOR, she should stop taking the drug and talk to her doctor at once. The active ingredient of ZOCOR did not cause birth defects inrats at 3 times the human dose or inrabbits at 3times the human dose. Nursing Mothers: Drugs taken by nursing mothers may be present intheir breast milk. Because of the potential for serious adverse reactions innurs ing infants, a woman taking ZOCOR should not breast-feed. (See WHEN ZOCOR SHOULD NOT BE USED.) Pediatric Use: ZOCOR is not recommended for children or patients under 10 years of age. Geriatric Use: Higher blood levels of active drug were seen in elderly patients (70-78 years of age) compared with younger patients (18-30 years of age) in1 study. Inother studies, the cholesterol-lowering effects of ZOCOR were at least as great inelderly patients as inyounger patients, and there were no overall differences insafety between elderly and younger patients over the 20-80 mg/day dosage range. Ofthe 7 cases of myopathy/rhabdomyolysis among 10,269 patients on ZOCOR inanother study, 4were aged 65 or more (at baseline), 1of whom was over 75. SIDE EFFECTS Most patients tolerate treatment with ZOCOR well; however, like all pre scription drugs, ZOCOR can cause side effects, and some of them can be serious. Side effects that do occur are usually mild and short-lived. Only your doctor can weigh the risks versus the benefits of any prescription drug. Inclin ical studies with ZOCOR, less than 1.5% of patients dropped out of the stud ies because of side effects. In2 large, 5-year studies, patients taking ZOCOR experienced similar side effects to those patients taking placebo (sugar pills). Some of the side effects that have been reported with ZOCOR or related drugs are listed below. This list is not complete. Be sure to ask your doctor about side effects before taking ZOCOR and to discuss any side effects that occur. Digestive System: Constipation, diarrhea, upset stomach, gas, heart burn, stomach pain/cramps, anorexia, loss of appetite, nausea, inflammation of the pancreas, hepatitis, jaundice, fatty changes inthe liver, and, rarely, severe liver damage and failure, cirrhosis, and liver cancer. Muscle, Skeletal: Muscle cramps, aches, pain, and weakness; joint pain; muscle breakdown. Nervous System: Dizziness, headache, insomnia, tingling, memory loss, damage to nerves causing weakness and/or loss of sensation and/or abnormal sensations, anxiety, depression, tremor, loss of balance, psychic disturbances. Skin: Rash, itching, hair loss, dryness, nodules, discoloration. Eye/Senses: Blurred vision, altered taste sensation, progression of cataracts, eye muscle weakness. Hypersensitivity (Allergic) Reactions: On rare occasions, a wide vari ety of symptoms have been reported to occur either alone or together ingroups (referred to as a syndrome) that appeared to be based on allergic-type reac tions, which may rarely be fatal. These have included 1 or more of the fol lowing: a severe generalized reaction that may include shortness of breath, wheezing, digestive symptoms, and low blood pressure and even shock; an allergic reaction with swelling of the face, lips, tongue, and/or throat with difficulty swallowing or breathing; symptoms mimicking lupus (a disorder in which a person's immune system may attack parts of his or her own body); severe muscle and blood vessel inflammation, sometimes including rash; bruises; various disorders of blood cells (that could result inanemia, infection, or blood clotting problems) or abnormal blood tests; inflamed or painful joints; hives; fatigue and weakness; sensitivity to sunlight; fever, chills; flushing; difficulty breathing; and severe skin disorders that vary from rash to a serious burn-like shedding of skin all over the body, including mucous membranes such as the lining of the mouth. Other: Loss of sexual desire, breast enlargement, impotence. Laboratory Tests: Liver function test abnormalities including elevated alkaline phosphatase and bilirubin; thyroid function abnormalities. NOTE: This summary provides important information about ZOCOR. Ifyou would like more information, ask your doctor or pharmacist to let you read the prescribing information and then discuss it with them. 0 MERCK WhitehouseStation,NJ 08889 ZOCOR is a registered trademark of Merck &Co., Inc. ©2004 Merck &Co., Inc. Allrights reserved. 20350263(3)(645C)-ZOC-CON When exercise is a pleasure, fitness is easy... Swim against a smooth current adjustable to any speed or ability. Ideal for exercise, water aerobics, rehabilitation and fun. Just 8' x 15', an Endless Pool" is simple to maintain, economical to run, and easy to install inside or out. For Our Free DVD or Video Call: (800) 233-0741. Ext. 3218 AUTHORS WANTED A well-known New York subsidy book pub lisher is searching for manuscripts. 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